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Magnetic resonance images are obtained before and after administration of the paramagnetic contrast agent, gadolinium. The segregation pattern of each DNA polymorphism within the family is then compared with the segregation of the Hybridization (a) banding pattern Chromosomal arrangement a1b1 b2a2 a3 Mutation at site a2 prevents cleavage a1b1b2 a3 from individual with both allele 1 and allele 2 Enzyme Enzyme AB Restriction endonuclease A Restriction endonuclease B Probed single-copy region (b) Grandparents 22 12 Alleles 1 2 3 Grandparents 22 23 Parent Parent 12 23 Children 23222223 22231212 Fragment lengths 10 kb 7.
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