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Cox-1 Cox-2 Constitutive expression Gastric epithelium, platelets Kidney, brain Inducible expression Rare or none under physiological conditions Induced in most tissues by growth factors, inflammatory cytokines, neurotransmitters, oxidative stress Effects Pain, platelet activation, protection of gastric mucosa Pain, inflammation, fever, angiogenesis, tumorigenesis Inhibited by Most NSAIDs, including aspirin; with minimal or no inhibition by Cox-2 selective agents Most NSAIDs Linoleic Acid 15-LOX-1 13-S-HODE 15-S-HETE Decreased cell proliferation, increased differentiation, promotion of apoptosis, attenuation of inflammatory response 15-LOX-2 12-S-LOX Arachidonic Acid 12-R-LOX 12-S-HETE 12-R-HETE 8-S-HETE LTB 4 Increased cell proliferation, promotion of tissue angiogenesis, suppression of tumor apoptosis, chemoattraction of inflammatory cells and potentiation of inflammatory response 8-LOX 5-LOX 5-S-HETE Figure 3 Products of lipoxygenase metabolism.
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INEAR SYSTEMS VIA Distinct Real Eigcnvalucs Complex Figenvalues Multiple Keal Eigenvalucs (177 EIGENVALUES 678 6X0 681 SOLVING LINEAK SYSTEMS BY SUBSTITUTION 682 STEADY Ctypto AND THEIR STABILITY 683 Stability of I. The complex of human activities directed to these four objec- tives is called economizing, and goods Cryptoo in the quantitative relationship involved in the preceding discussion are the exclusive objects of it.
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